FLASH 疗法是在通常小于 1 秒的时间内以超高剂量率向治疗部位实施放射治疗的一种实验性治疗模式。
FLASH 疗法可能是近数十年来癌症治疗领域最重要的进展之一。
FLASH 疗法是在通常小于 1 秒的时间内以超高剂量率向治疗部位实施放射治疗的一种实验性治疗模式。使用小鼠的临床前研究已证明，FLASH 疗法与传统疗法相比，肿瘤控制效果相当或更好，正常组织毒性更小，且具有免疫优势。
瓦里安的 FlashForward™ 联盟由世界各地的机构成员组成，致力于制定临床前研究设计、开发技术解决方案，分享科研规范，协助推进 FLASH 疗法的学术和临床转化。
Consortium members
- CHUV Lausanne University Hospital
- Cincinnati Children's/UC Health Proton Therapy Center
- Danish Centre for Particle Therapy
- Guangzhou Concord Cancer Center
- Haukeland University Hospital
- Hefei Ion Medical Center
- Holland Proton Therapy Centre
- Institut Curie
- King Chulalongkorn Memorial Hospital
- Midwest Cancer Center
- Mount Sinai Hospital
- Montefiore Medical Center
- The Ohio State University
- New York Proton Center
- Oslo University Proton Therapy Center
- Paul Scherrer Institute
- Penn Medicine
- Shandong Proton Therapy Center
- Singapore Proton Therapy Center
- South Florida Proton Therapy Institute
- St. Petersburg Proton Therapy Center
- The Christie Proton Therapy Centre
- University College London
- University Hospital Zurich
- University of Alabama at Birmingham
- University of Maryland Department of Radiation Oncology
- University of Miami Sylvester Comprehensive Cancer Center
- VU University Medical Center Amsterdam
世界首次 FLASH 临床试验
FLASH 质子放射治疗用于症状性骨转移癌的可行性研究（FAST-01）
FAST-01 是首次人体临床试验，该试验评估 FLASH 放射治疗用于四肢骨转移骨痛患者的可行性和安全性。单次放疗使用 FLASH 剂量率以 250 兆电子伏质子束给予标准的 8 Gy 姑息治疗分割剂量。FAST-01 研究正在辛辛那提儿童医院医疗中心积极招募年满 18 岁的符合条件的患者（主要研究者：J. Breneman 博士）。随访试验 FAST-02 正在设计中。
研究详情：
- 四肢骨转移癌患者
- 该研究正在开放招募受试者
- 该研究使用改良的 ProBeam 来获得临床研究器械豁免 (IDE)
- 与辛辛那提儿童/辛辛那提大学医疗中心、质子治疗中心合作
欲知详情，请参阅 FLASH 质子放射治疗用于症状性骨转移癌的可行性研究 。
Trials using FLASH radiotherapy for lung cancer and other malignancies are currently being developed. Using FLASH treatment for these cancers could deliver higher cancer-killing doses without causing inordinate side effects, which would be a real advance.
FLASH therapy has the potential to be practice-changing and drastically improve the experience of cancer care for a new generation of patients. The launch of the first FLASH clinical trial, a project that has come to fruition after years of intensive study, is an important milestone in the progress of radiation therapy.